Secondary nonresponsiveness to botulinum toxin A in cervical dystonia: The role of electromyogram‐guided injections, botulinum toxin A antibody assay, and the extensor digitorum brevis test
Identifieur interne : 003196 ( Main/Exploration ); précédent : 003195; suivant : 003197Secondary nonresponsiveness to botulinum toxin A in cervical dystonia: The role of electromyogram‐guided injections, botulinum toxin A antibody assay, and the extensor digitorum brevis test
Auteurs : Carla Cordivari [Royaume-Uni] ; Vijay Peter Misra [Royaume-Uni] ; Angela Vincent [Royaume-Uni] ; Santiago Catania [Royaume-Uni] ; Kailash P. Bhatia [Royaume-Uni] ; Andrew John Lees [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Action Potentials (drug effects), Antibodies, Blocking (blood), Bontoxilysin, Botulinum Toxins, Type A (administration & dosage), Botulinum Toxins, Type A (immunology), Drug Resistance, Dystonia, EDB text, EMG, Electric Stimulation, Electromyography, Electromyography (drug effects), Humans, Injections, Intramuscular, Muscle, Skeletal (innervation), Nervous system diseases, Retreatment, Torticollis (drug therapy), Torticollis (immunology), botulinum toxin, secondary nonresponders.
- MESH :
- chemical , administration & dosage : Botulinum Toxins, Type A.
- chemical , blood : Antibodies, Blocking.
- drug effects : Action Potentials, Electromyography.
- drug therapy : Torticollis.
- chemical , immunology : Botulinum Toxins, Type A, Torticollis.
- innervation : Muscle, Skeletal.
- Drug Resistance, Electric Stimulation, Humans, Injections, Intramuscular, Retreatment.
Abstract
We studied 20 patients with cervical dystonia who had started to respond poorly to botulinum toxin A (BTXA) injections after an initial good response. All patients had extensor digitorum brevis (EDB) tests performed in addition to BTXA immunoprecipition assay (IPA) and mouse bioassay (MBA) antibody testing. The patients were reexamined and then treated with carefully placed electromyogram (EMG)‐guided BTXA. Nine patients had a good clinical response to EMG‐guided injections and all of these patients showed an obvious decrement on the EDB test. All were BTXA blocking antibodies (Abs)–negative via IPA and MBA (apart from one patient who had low BTXA antibodies titers using IPA but no antibodies by MBA). In the other 11 patients, there was a poor clinical response to EMG‐guided BTXA injections. Seven of these 11 had small EDB decrement and BTXA antibodies using IPA, suggesting resistance to BTXA. Of the remaining four patients, two had obvious EDB decrement and low antibody titers via IPA (one of them had no antibodies via MBA), while the other two patients showed obvious decrement on the EDB test and no antibodies via IPA. This study shows that the EDB test correlates better with the clinical response than the antibody assays and that EDB decrement does not always correlate quantitatively with the BTXA antibody titers. In patients with secondary nonresponsiveness, it is recommended that an EDB test is the initial investigation of choice. In those patients where the EDB test does not demonstrate resistance to BTXA, a reexamination of the patients and carefully placed injections under EMG guidance may improve results. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21051
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-10">2006-10</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1737">1737</biblScope><biblScope unit="page" to="1741">1741</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1EC380FA1E4DF43533F026BC813A1BE747613CB1</idno><idno type="DOI">10.1002/mds.21051</idno><idno type="ArticleID">MDS21051</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials (drug effects)</term><term>Antibodies, Blocking (blood)</term><term>Bontoxilysin</term><term>Botulinum Toxins, Type A (administration & dosage)</term><term>Botulinum Toxins, Type A (immunology)</term><term>Drug Resistance</term><term>Dystonia</term><term>EDB text</term><term>EMG</term><term>Electric Stimulation</term><term>Electromyography</term><term>Electromyography (drug effects)</term><term>Humans</term><term>Injections, Intramuscular</term><term>Muscle, Skeletal (innervation)</term><term>Nervous system diseases</term><term>Retreatment</term><term>Torticollis (drug therapy)</term><term>Torticollis (immunology)</term><term>botulinum toxin</term><term>secondary nonresponders</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Botulinum Toxins, Type A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Blocking</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Action Potentials</term><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Torticollis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Botulinum Toxins, Type A</term><term>Torticollis</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Resistance</term><term>Electric Stimulation</term><term>Humans</term><term>Injections, Intramuscular</term><term>Retreatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Bontoxilysin</term><term>Dystonie</term><term>Electromyographie</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied 20 patients with cervical dystonia who had started to respond poorly to botulinum toxin A (BTXA) injections after an initial good response. All patients had extensor digitorum brevis (EDB) tests performed in addition to BTXA immunoprecipition assay (IPA) and mouse bioassay (MBA) antibody testing. The patients were reexamined and then treated with carefully placed electromyogram (EMG)‐guided BTXA. Nine patients had a good clinical response to EMG‐guided injections and all of these patients showed an obvious decrement on the EDB test. All were BTXA blocking antibodies (Abs)–negative via IPA and MBA (apart from one patient who had low BTXA antibodies titers using IPA but no antibodies by MBA). In the other 11 patients, there was a poor clinical response to EMG‐guided BTXA injections. Seven of these 11 had small EDB decrement and BTXA antibodies using IPA, suggesting resistance to BTXA. Of the remaining four patients, two had obvious EDB decrement and low antibody titers via IPA (one of them had no antibodies via MBA), while the other two patients showed obvious decrement on the EDB test and no antibodies via IPA. This study shows that the EDB test correlates better with the clinical response than the antibody assays and that EDB decrement does not always correlate quantitatively with the BTXA antibody titers. In patients with secondary nonresponsiveness, it is recommended that an EDB test is the initial investigation of choice. In those patients where the EDB test does not demonstrate resistance to BTXA, a reexamination of the patients and carefully placed injections under EMG guidance may improve results. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Oxfordshire</li></region><settlement><li>Londres</li><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Cordivari, Carla" sort="Cordivari, Carla" uniqKey="Cordivari C" first="Carla" last="Cordivari">Carla Cordivari</name></region><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><name sortKey="Catania, Santiago" sort="Catania, Santiago" uniqKey="Catania S" first="Santiago" last="Catania">Santiago Catania</name><name sortKey="Lees, Andrew John" sort="Lees, Andrew John" uniqKey="Lees A" first="Andrew John" last="Lees">Andrew John Lees</name><name sortKey="Misra, Vijay Peter" sort="Misra, Vijay Peter" uniqKey="Misra V" first="Vijay Peter" last="Misra">Vijay Peter Misra</name><name sortKey="Vincent, Angela" sort="Vincent, Angela" uniqKey="Vincent A" first="Angela" last="Vincent">Angela Vincent</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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